| The Forgotten Hormone Vitamin D3 |
| Vitamin D3 (1,25(OH)2D3) The sun is our most important source of vitamin D. Exposure to the sun, in moderate doses, also gives large amounts of this vitamin. The ultraviolet radiation in these sources converts 7-dihydrocholesterol to previtamin D3 in the skin. Furthermore, heat isomerization to vitamin D3 takes place, then transport to the liver and hydroxylation to calcidiol, which is transported to the kidneys and hydroxylated to the active hormone calcitriol. The vitamin D3 status of the body is supposed to be reliably imaged by calcidiol measurements. Vitamin D3 is actually considered a hormone because it made in the body by ultraviolet radiation from the sun on 7-dihydrocholesterol. Vitamin D3 is not politically correct. It discriminates depending where you live, the further you live from the equator the less sun exposure consequently the lower your Vitamin D3 level. It discriminates against the elderly, as you age your skin loses up to 75% of its ability to make Vitamin D3. It discriminates against the obese. They have lower levels of Vitamin D3, due to the fact it is oil soluble, that it builds up in the fat tissue. It discriminates against skin color a dark complected person needs more sun exposure to produce their Vitamin D3 than a fair skinned person. It also discriminates against a person who does as they are told. It has been reported the incident of breast cancers have increased 40% in Australia due to Vitamin D3 deficiency caused by sunscreen use. Vitamin D3 is responsible for regulating the calcium and phosphorus levels in the blood by their absorption from food and re-absorption of calcium in the kidney. It promotes bone formation and is essential in the development of strong bones. It also inhibits paraththyroid hormone secretion from the parathyroid gland. Vitamin D affects the immune system by promoting immunosuppression and anti-tumor activity. “Osteoporosis and Low Bone Mass - Females and Males
The correct test is 25(OH)D, also called 25-hydroxyvitamin D M. F. Holick, Department of Medicine, Boston University Medical Center, MA stated in Bone August 17 1995 that 1,25(OH)2D3 is a potent antiproliferative and prodifferentiation mediator. As a result, 1,25(OH)2D3 and its analogs have wide clinical application in such diverse clinical disorders as:
His reply was "Drisdol is a prescription of 50,000 IU tablets of ergocalciferol or D2. Ergocalciferol is not vitamin D but it is similar. It is made by irradiating ergosterol, which is found in many living things, such as yeast. D2 is not normally found in humans and most studies show it does not raise 25(OH)D levels as well as human vitamin D (cholecalciferol or D3) does. However, Drisdol is a lot better than nothing. The best thing to do, if you are vitamin D deficient, and a human, is to take human vitamin D, cholecalciferol, A.K.A. vitamin D3." Vitamin D2 Is Much Less Effective than Vitamin D3 The injectables and transdermals have given the good responses, according to feedback from physicians. We have recently had a patient, with a blood level of 17 nmol/l go to 93 nmol/l using our 100,000 unit capsules of vitamin D2 & vitamin D3 in three months. However, recently we are see most precriptions are for Vitamin D3 100,000 unit capsules. These capsules a dosages from twice a week to every other week, with follow up blod levels. We can prepare the dosage form and strength ordered by your physician. Contact: Partners In Care Vitamin D3 General Vitamin D2 Is Much Less Effective than Vitamin D3 Vitamin D deficiency: A global perspective. What Is the Effect of Vitamin D Deficiency During Pregnancy? Vitamin D: A Hormone for All Seasons - How much is enough? Understanding the New Pressures Adiposity in Relation to Vitamin D Status and Parathyroid Hormone Levels: A Population-Based Study in Older Men and Women Body Fat Content and 25-Hydroxyvitamin D Levels in Healthy Women Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. The vitamin D epidemic and its health consequences. Barriers to optimizing vitamin D3 intake for the elderly. Hypovitaminosis D prevalence and determinants among African American and white women of reproductive age: third National Health and Nutrition Examination Survey, 1988-1994. Noncalcemic actions of 1,25-dihydroxyvitamin D3 and clinical applications. Prevalence of vitamin D insufficiency in Canada and the United States: importance to health status and efficacy of current food fortification and dietary supplement use. Racial/ethnic considerations in making recommendations for vitamin D for adult and elderly men and women. Ultraviolet light may contribute to geographic and racial blood pressure differences. Vitamin D and African Americans. Vitamin D3 Cancer Analysis of 25-hydroxyvitamin D3-1alpha-hydroxylase in normal and malignant breast tissue. Vitamin D status and breast cancer risk. Calcitriol in cancer treatment: From the lab to the clinic. Epigenetic corruption of VDR signaling in malignancy. Calcitriol in the treatment of prostate cancer. Both high and low levels of blood vitamin D are associated with a higher prostate cancer risk: a longitudinal, nested case-control study in the Nordic countries. Inhibition of angiogenesis by vitamin D-binding protein: Characterization of anti-endothelial activity of DBP-maf. Regulation of vitamin D receptor expression via estrogen-induced activation of the ERK 1/2 signaling pathway in colon and breast cancer cells. Vitamin D compounds: clinical development as cancer therapy and prevention agents. Vitamin D metabolism in human prostate cells: implications for prostate cancer chemoprevention by vitamin D. 1,25-Dihydroxyvitamin D3 suppresses exportin expression in human promyelocytic leukemia HL-60 cells. Vitamin D3 Arthritis & Immune System D-hormone and the immune system. Hormone replacement therapy, calcium and vitamin VITAMIN D3 versus calcium and vitamin D3 alone decreases markers of cartilage and bone metabolism in rheumatoid arthritis: a randomized controlled trial [ISRCTN46523456]. Positive association between serum 25-hydroxyvitamin D level and bone density in osteoarthritis. Circannual vitamin d serum levels and disease activity in rheumatoid arthritis: Northern versus Southern Europe. Vitamin D deficiency and chronic low back pain in Saudi Arabia. 1alpha,25-dihydroxy-vitamin D3 stimulation of bronchial smooth muscle cells induces autocrine, contractility, and remodeling processes. Fibroblast growth factor 2 and transforming growth factor beta1 synergism in human bronchial smooth muscle cell proliferation. IL-10 signaling is essential for 1,25-dihydroxyvitamin D3-mediated inhibition of experimental autoimmune encephalomyelitis. Vitamin D3 Diabetes Low Serum 25-Hydroxyvitamin D Concentrations are Associated with Insulin Resistance and Obesity in Women with Polycystic Ovary Syndrome. Feasibility of a type 1 diabetes primary prevention trial using 2000 IU vitamin D3 in infants from the general population with increased HLA-associated risk. Protection from type 1 diabetes by vitamin D receptor haplotypes. Monocytes from type 2 diabetic patients have a pro-inflammatory profile 1,25-Dihydroxyvitamin D(3) works as anti-inflammatory. Serum 25-hydroxyvitamin D3 concentrations and carotid artery intima-media thickness among type 2 diabetic patients. The effect of vitamin D3 on insulin secretion and peripheral insulin sensitivity in type 2 diabetic patients. A multicenter, double-blind, safety study of QR-333 for the treatment of symptomatic diabetic peripheral neuropathy. A preliminary report. |