Estriol is the main estrogen in pregnancy, but its other benefits are now receiving attention. It is well known that pregnancy has an immunosuppressive effect on many autoimmune diseases such as multiple sclerosis, psoriasis, thyroiditis, uveitis, and rheumatoid arthritis. Emerging evidence indicates that estriol has potential immunomodulatory benefits for many disease states including autoimmune, inflammatory, and neurodegenerative conditions.
Rethinking Hormone Therapy
The North American Menopause Society (NAMS) released its 2017 Hormone Therapy Position Statement (1), which said:
• Hormone therapy (HT) remains the most effective treatment for vasomotor symptoms (like hot flashes), problems with the genitourinary tract, and has been shown to prevent bone loss and fracture.
• The risks of HT differ depending on the specific hormone, dose, duration of use, route of administration, timing of initiation, and which type of progestogen (i.e., synthetic progestin or natural progesterone) is used.
• Treatment should be individualized to maximize benefits and minimize risks.